|
KMID : 1123920050190061659
|
|
Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 6 p.1659 ~ p.1665
|
|
|
Gamipaidok-san Possesses Antiallergic and Anti-inflammatory Activities
|
|
Kim Dae-Nam
Kim Ji-Young
Han Eun-Hee
Oh Kyo-Nyeo
Kim Sung-Hoon
Jin Mi-Rim
Jeong Hye-Gwang
Kim Dong-Hee
|
|
|
Abstract
|
|
|
|
Gamipaidok-san(GPDS) is the Hyungbangpaidok-san prescription fortified with the additional ingredients known to be effective for dermatitis. So it has been used for atopic dermatitis in the clinic work actually. In this study, we investigated the effects of GPDS on in vitro and in vivo anti-allergic effect on RBL-2H3 rat basophilic leukemia Cells and on IgE-induced passive cutaneous anaphylaxis (PCA) in mice. The in vitro anti-inflammatory activity of GPDS in RAW 264.7 cells was investigated. GPDS potently inhibited -hexosaminidase release from RBL-2H3 and the IgE-mediated PCA reaction in mice. GPDS inhibited LPS-induced NO and PGE2 production in a dose-dependent manner Furthermore, It also inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in RAW 264.7 cells, and the activation of the transcription factor, NF-kB, in nuclear fraction. The antiallergic action of GPDS may originate from anti-inflammatory activities, and can improve the inflammation caused by allergies.
|
|
|
KEYWORD
|
|
|
Gamipaidok-san(GPDS), inflammation, allergy, RAW 264.7 cells, -hexosaminidase, Nitric oxide, PGE2, COX-2, iNOS, NF-kB
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|